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COST B14 Protocols

After it's first year of operation, the COST B14 Action formed several working groups, each coordinating a COST supported study project. These working groups have elaborated prospective study protocols in their field of interest. These protocols are available for viewing and downloading in the sections linked to from below. All HBO-scientists and other medical professionals are strongly encouraged to participate in these studies - the COST Working Group acting as coordinators.

All these protocols have been prepared according to the HBO Research Quality Guidelines Document prepared by Working Group B (Final Report)

Working Group Protocol Other documents Coordinator Participants
WG 1

HBO in the Treatment of Sudden Deafness (English)

HBO in the Treatment of Sudden Deafness (Danish)

Informed Consent (English)
Informed Consent (French)
Informed Consent (Dutch)
Data Collection form (English)
Investigator Agreement
Ethic Committee Approvals

Dr Alain Barthélémy (Fr) Brussels (Be)
Roma (It)
Marseille (Fr)
Angers (Fr)
Brest (Fr)
Strasbourg (Fr)
Lyon (Fr)
Bordeaux (Fr)
Traunstein (GE)
WG 2 HBO in the Treatment of Femoral Head Necrosis Evolution Form (English) Dr Luciano Ditri (It)
WG 3 Role of hyperbaric oxygen in enhancing radiosensitivity on glioblastoma multiforme Dr Urlich M. Carl (GE)
WG 3 Re-irradiation of recurrent squamous cell carcinoma of the head and neck (SCCHN) after HBO sensitization Dr K. Axel Hartmann (GE)
WG 3 Osseointegration in irradiated patients. Adjunctive HBO to prevent implant failures

Dr Gosta Granstrom (S)


WG 4 HBO in the Treatment of Diabetic Foot Lesions

Screening Form
Informed Consent Form
Case Report Form
Adverse Events Form

Ethic Committee Approvals

Dr Daniel Mathieu (Fr) Pilzen (CZ)
Lisbon (P)
Turku (Fi)
Lille (Fr)
Ravenna (It)
Thessaloniki (Gr)

The Working Group 3 "Oncology" prepared the overview of HBO and radiotherapy with the presentation of several protocols for randomized clinical studies. The publication from Strahlentherapie und Onkologie (2005; 181: 113-123) can be freely downloaded (here) thanks to publishers: Springer (www.springerlink.com) and Urban & Vogel GmbH (www.urban-vogel.de).

Other preliminary protocols have been submitted to the Management Committee. Although only five research protocols were chosen to be implemented via a Working Group, many of the other protocols are potentially of great interest to the HBO community. These other, unfinished and (in most cases) draft protocols are listed below. Each protocol has a brief description attached, and an e-mail link to the author or promotor of the protocol.

Title of Protocol
Chronic carbon monoxide intoxication treated with or without hyperbaric oxygen treatment 
HBO as adjunct therapy in refractory or fistulizing Crohn's Disease
HBO in the multidisciplinary treatment of upper limb trauma
Evaluation of the efficacy of Comex 30 He-O2 vs. US Navy treatment tables 
HBO in the treatment of intrauterine growth retardation 
Treatment of Sympathetic Reflex Dystrophy (SRD) with Hyperbaric Oxygen Therapy
HBO in the acute treatment of thermal burn wounds